City Police say Michelle Adrian, 17, and a friend went into an alley Tuesday morning looking to buy drugs.
A man approached their truck, threatened them and then fired several shots into the cab before taking off.
Adrian died a short time later at Shock Trauma from her injuries.
Her friend, who has not been identified, is still being treated for his injuries.
Police arrested and charged Dorrien Allen of Baltimore for the murder and other offenses.
He's being held at the Baltimore City Detention Center without bail.