"This is the biggest storm this entire region has seen since the past couple of years since the blizzard during the year of 2010," says WHAG Meteorologist Alan Auglis.
Roads in the four-state region are being treated with the traditional salt brine, which is basically just salt and water.
"That stays on the road surface so that when the storm begins the ice doesn't stick to the pavement and that helps our crew stay ahead of the game," says Heather Keels, with the State Highway Administration.
But on certain, busier, roads crews are using a special ingredient.
"De-sugared beet molasses which lowers the freezing point of the brine," says Keels. "It makes it more effective and it allows it to stay on the road longer so you can pre-treat further in advance of a storm and still have it be effective."
But meteorologists and road crews aren't the only ones ready for some action
"We've seen an increase in sales on milk, egg, bread some of the perishable items in the produce salt and snow shovels," say Eric Hahn, store manager of Weis supermarket.
No matter the industry they're all thinking of one thing, your safety.
"Your commute is going to be impacted with several inches of snow so definitely leave some extra time for your commute," says Meteorologist Auglis
"See if you can stay home or delay travel at all if possible," says Keels. "If you do have to get out there on the road make sure you allow for extra time and take it slow."
Click here for tips on how to prepare for a snow storm.