Police say Zakria Hussain, 16, and Colin Lauterback, 18, were last seen Tuesday, February 26 around 8 p.m.
Police say Hussain is described as of middle eastern descent with short brown hair and brown eyes. Hussain is 5'5" and weighs 130 lbs.
Police say Lauterbach is described as a white male with brown hair and brown eyes. Lauterbach is 5'8" and weighs 156 lbs.
Both males were last spotted in the Williamsport area.
Police are asking anyone with information on the location of the two teenagers are asked to contact the Washington County Sheriff's Department at (240)-313-2170.