Police say it happened around 2:00 p.m. at the 8-mile marker near the Tabler Station Road exit.
They say Guier was heading north on I-81 when she lost control, went over the median and struck another vehicle, driven by Ashley French on the southbound side.
Police say a third vehicle was also caught up in the crash. The debris from the first two cars caused Ann Prince to crash her vehicle.
French and Prince did not suffer any injuries.