Officials say the explosion happened near Green Ridge Road and Crooked Run Road near the Columbia Gas plant.
Fire crews were on the scene for several hours, trying to control the fire.
Fire and Rescue officials in Allegheny County, MD. say residents were evacuated, and shelters have been set up at the community center in Artemas and at the Little Orleans fire department.
No one was injured after this explosion, but officials have not released the cause of the explosion.