Police say it happened at 5:55 p.m. on Route 340 west.
Officials say 56-year old David Forward, of Frederick, was driving his car east on Rt. 340, when he crossed over and hit a tractor trailer going west.
EMS had to remove Forward from his vehicle and he was pronounced dead at the scene.
They say the driver of the tractor trailer, Gregory Givens, was taken to the hospital with minor injuries.
At this time there are no charges pending and the investigation continues.